Potentiation of Ca-induced Ca release mechanism by methylxanthines. Caffeine vs. others.
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Suramin and Disulfonated Stilbene Derivatives Stimulate the Ca -Induced Ca -Release Mechanism in A7r5 Cells
We have described previously a novel Ca -induced Ca release (CICR) mechanism in permeabilized A7r5 cells (embryonic rat aorta) and 16HBE14ocells (human bronchial mucosa) cells (J Biol Chem 278:27548–27555, 2003). This CICR mechanism was activated upon the elevation of the free cytosolic calcium concentration [Ca ]c and was not inhibited by pharmacological inhibitors of the inositol-1,4,5-trisph...
متن کاملStretch-induced Ca release via an IP3-insensitive Ca channel
Mohanty, Madhumita Jena, and Xingli Li. Stretchinduced Ca2 release via an IP3-insensitive Ca2 channel. Am J Physiol Cell Physiol 283: C456–C462, 2002. First published May 15, 2002; 10.1152/ajpcell.00057.2002.—Various mechanical stimuli increase the intracellular Ca2 concentration ([Ca2 ]i) in vascular smooth muscle cells (VSMC). A part of the increase in [Ca2 ]i is due to the release of Ca2 fro...
متن کاملCa-induced Ca release: lessons regarding cell models.
THIS MONOLOG is part of an APS series on major findings that have shaped many of our present concepts regarding what we currently understand as physiology. The process of Ca-induced Ca release was a topic of much discussion and debate when first introduced. The seminal manuscript on this topic is often considered that of Alexandre Fabiato, “Calcium-induced release of calcium from the cardiac sa...
متن کاملNicotinate-adenine dinucleotide phosphate-induced Ca(2+)-release does not behave as a Ca(2+)-induced Ca(2+)-release system.
We investigated the dependence of nicotinate-adenine dinucleotide phosphate (NAADP)-induced Ca2+ release from intracellular stores of sea urchin egg homogenates, upon extravesicular Ca2+. In contrast to the Ca2+ release induced inositol 1',4',5'-triphosphate (IP3) or cyclic ADP-ribose (cADPR), the Ca2+ release induced by NAADP was completely independent of the free extravesicular Ca2+ over a wi...
متن کاملLuminal Ca Controls Termination and Refractory Behavior of Ca -Induced Ca Release in Cardiac Myocytes
Despite extensive research, the mechanisms responsible for the graded nature and early termination of Ca -induced Ca release (CICR) from the sarcoplasmic reticulum (SR) in cardiac muscle remain poorly understood. Suggested mechanisms include cytosolic Ca -dependent inactivation/adaptation and luminal Ca -dependent deactivtion of the SR Ca release channels/ryanodine receptors (RyRs). To explore ...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1991
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)39359-x